He is also an Investigator of the Howard Hughes Medical Institute. Booker received a BA in Chemistry from Austin College in 1987 and a Ph.D. in Biochemistry from the Massachusetts Institute of Technology in 1994. After postdoctoral studies at the Université René Descartes (Paris, France) and the University of Wisconsin–Madison, he moved to Penn State University in 1999 as an independent investigator before assuming his current position at Penn in 2025. Booker’s research focuses on enzymes that catalyze reactions using radicals. He is an Associate Editor for Biochemistry ACS and Deputy Editor for ACS Bio & Med Chem Gold. He is also a member of the American Academy of Arts and Sciences and the National Academy of Sciences.